The pair played siblings Nick and Noelle Kringle in the 2019 Disney+ Christmas movie Noelle before a source to PEOPLE in January 2022.
Anna Kendrick and Bill Hader
The Guardians of the Galaxy star dated his Everwood costar from 2004 to 2007, after the pair met on set and played siblings Bright and Amy Abbott.
Chris Pratt & Emily VanCamp
VanCamp moved on from one onscreen sibling to another: in 2007, after her split from Pratt, she briefly dated her (no joke) Brothers and Sisters costar Dave Annable, who played her character Rebecca's half-brother Justin.
Emily VanCamp & Dave Annable
Dan Humphrey and Serena van der Woodsen's chemistry transcended the boundaries of the screen and of learning they were step-siblings: in real life, Lively and Badgley dated from 2007 to 2010.
Blake Lively & Penn Badgley
Hall and Carpenter met on the set of Dexter, where they played siblings Dexter and Debra Morgan. They began dating soon after they first met, and eloped on New Year's Eve in 2008. After two years of marriage, they filed for in 2010, while they continued to star on the show together until the 2012 finale.
Michael C. Hall & Jennifer Carpenter
The Lost alumni met on the set of the hit show in 2004, in which they played step-siblings Boone Carlyle and Shannon Rutherford. They started dating after both of their characters got killed off the series, and stayed together until 2007.
Ian Somerhalder & Maggie Grace
The Beverly Hills, 90210 stars famously played twins Brandon and Brenda Walsh. Years after the long-running teen drama ended, Priestley admitted to Howard Stern that he and Doherty had briefly dated during the show's first season. In his memoir, Jason Priestley: A Memoir, he wrote, "various combinations of people slept with each other over the years."
Shannen Doherty & Jason Priestley